Liquid chromatography

Liquid chromatography (LC) is a powerful analytical technique capable of separating, identifying, and quantifying nonvolatile or thermally labile constituents in complex matrices.

Liquid chromatography and LC coupled with mass spectrometry (LC/MS) have many applications including the identification and quantification of surfactants, additives and stabilizer packages in various polymers, for identification of degradation products, and for quantification of ppb levels of residual target compounds or impurities in process streams, final products, or reaction mixtures.


The analytes are separated as they pass through a column using reverse phase liquid chromatography. An ultraviolet (UV) detector is often used to detect the separated species based on retention time. The separated analytes may alternatively be ionized by a mass spectrometer, which allows determination of molecular weight and molecular structure.  Arkema Analytical Solutions has various ionization sources including electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and atmospheric pressure photoionization (APPI). These allow the detection of a vast array of polar and non-polar compounds. The sensitivity and selectivity of our triple quadrupole (MS/MS) spectrometer enables quantification of target analytes at ppb levels. Our ion-trap mass spectrometer allows for structural elucidation of numerous analytes in complex mixtures in a single experiment using the multistage fragmentation capability (MSn).