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Formulation development and formulation optimization

Design of Experiments (DOE) and statistical experimental analysis have been widely applied in formulation development and are useful in formulation optimization. 

The main advantages of adopting DOE to develop formulation grades lie in the fact that it allows potential factors to be evaluated simultaneously, systematically, and efficiently. Using DOE principles, our team of experts can evaluate the effects of formulation factors on each response and quickly identify the critical factors based on statistical analysis. After the critical factors have been pinpointed, the optimal formulations can be searched by optimizing the levels of all responses. When the formulations are optimized by a systematic approach using DOE, the scale-up process can be very efficient because of the robustness of the developed formulations.

Example flow chart for formulation development and optimization
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